PropertyValue
?:abstract
  • A recent study in vitro has shown that a sulphated polysaccharide, a type of fucoidan, has potent antiviral activity against SARS-Cov2. If the antiviral action were successful also for COVID-19 patients, it would be enormously valuable against not only acute disease but also long-term mental effects, which might include Alzheimer\'s disease (AD). In a trial of AD patients, the apparent success of treatment with a polysaccharide, GV971, was suggested to result from antiviral action against herpes simplex virus type 1 (HSV1) in brain, a pathogen strongly implicated in AD, and that sulphation of GV971, making it fucoidan-like, might increase its putative antiviral action. These data indicate that treatment of AD patients might be very effective using valacyclovir, a conventional antiviral, which inhibits viral replication, together with a fucoidan, which blocks virus entry into cells.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3233/jad-200986
?:journal
  • Journal_of_Alzheimer\'s_disease_:_JAD
?:license
  • unk
?:pmid
?:pmid
  • 33074241.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • Medline
?:title
  • Antivirals Against SARS-CoV2: Relevance to the Treatment of Alzheimer\'s Disease.
?:type
?:year
  • 2020-10-13

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