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BACKGROUND: During the COVID-19 pandemic, the Albanian authorities declared mandatory stay-at-home measures, closing businesses, schools, and public places. This study aims to investigate the impact of these immediate changes on the mental well-being of the population. METHODOLOGY: Respondents (N = 1678) aged 18–60 years were selected through a convenient sampling method. A questionnaire was administered online for 26 days, where respondents reported the time spent daily in the COVID-19 topic and filled in their generalities, the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7. RESULTS: Findings suggest a significant negative correlation between age and anxiety scoring (r ((n) =( 1678)) = −0.121, P ≤ 0.001) and between age and depression scoring (r ((n) =( 1678)) = −0.232, P ≤ 0.001), shown also on the ANOVA test for age and anxiety (F = 6.019, P ≤ 0.05), where younger populations had higher anxiety levels, as well as age and depression (F = 20.326, P ≤ 0.05), where older populations had higher levels of depression. Differences on the level of education resulted in a lower score of anxiety and depression (F = 3.524, P ≤ 0.05; F = 7.739, P ≤ 0.05, respectively) on respondents with higher education. Those who found themselves jobless from the pandemic scored higher on anxiety and depression (F = 9.760, P ≤ 0.05; M = 6.21, ds = 4.686 and F = 16.051, P ≤ 0.05; M = 8.18, ds = 5.791, respectively) compared with those who are still working. Significant differences were found on the ANOVA test related to different amounts of time spent daily on the COVID-19 topic for anxiety and depression (F = 25.736, P ≤ 0.001; F = 5.936, P ≤ 0.003, respectively), with people who spend <1 h scoring higher on depression (M = 7.57, ds = 5.849) and those who spent >3 h scoring higher on anxiety (M = 6.76, ds = 5.60). On the t-test, people on a romantic relationship scored lower levels of depression (t = −4.053, P ≤ 0.0001) compared to single individuals, and females scored higher levels of anxiety (t = 12.344, P ≤ 0.001) compared to males. CONCLUSIONS: Younger participants score higher levels of anxiety and depression. Higher education individuals show lower levels of anxiety and depression. Having a job translates into lower levels of anxiety and depression. People who spent more time on the COVID-19 topic daily have higher levels of anxiety, whereas those who spent less time have higher levels of depression. Being in a romantic relationship relates to lower levels of depression. Females report higher levels of anxiety compared to males.
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