suk1vt1c

Property	Value
?:abstract	Abstract B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27?, CD21?) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either ?driver or passenger? of hyperinflammation during COVID-19 needs to be clarified B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27(-), CD21(-)) atypical memory B cells and (CD19(+), CD27(+), CD38(+)) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73(+) B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either \'driver or passenger\' of hyperinflammation during COVID-19 needs to be clarified B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27–, CD21–) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needs to be clarified
is ?:annotates of	<https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C0021368> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C1332822> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C1413696> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C1417861> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C1418401> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C3811765> <https://research.tib.eu/covid-19/entity/suk1vt1c_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Wildner%2C_N._H.%3B_Ahmadi%2C_P.%3B_Schulte%2C_S.%3B_Brauneck%2C_F.%3B_Kohsar%2C_M.%3B_L%C3%BCtgehetmann%2C_M.%3B_Beisel%2C_C.%3B_Addo%2C_M._M.%3B_Haag%2C_F.%3B_Schulze_zur_Wiesch%2C_J.> <https://research.tib.eu/covid-19/entity/Wildner%2C_N._H.%3B_Ahmadi%2C_P.%3B_Schulte%2C_S.%3B_Brauneck%2C_F.%3B_Kohsar%2C_M.%3B_Lutgehetmann%2C_M.%3B_Beisel%2C_C.%3B_Addo%2C_M._M.%3B_Haag%2C_F.%3B_zur_Wiesch%2C_J._S.> <https://research.tib.eu/covid-19/entity/Wildner%2C_Nils_H.%3B_Ahmadi%2C_Parimah_Schulte_Sophia_Brauneck_Franziska_Kohsar_Matin_L%C3%BCtgehetmann_Marc_Beisel_Claudia_Addo_Marylyn_M.%3B_Haag%2C_Friedrich_Schulze_zur_Wiesch_Julian>
?:journal	Journal_of_Leukocyte_Biology
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/suk1vt1c_HAS_C1332822_STIMULATES_C0004561> <https://research.tib.eu/covid-19/entity/suk1vt1c_HAS_C1418401_STIMULATES_C0004561> <https://research.tib.eu/covid-19/entity/suk1vt1c_HAS_C3811765_STIMULATES_C0004561>
?:source	WHO
?:title	B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1023293 #956712 #978134
?:year	2020 2021

Property

Value

?:abstract

Abstract B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27?, CD21?) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either ?driver or passenger? of hyperinflammation during COVID-19 needs to be clarified
B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27(-), CD21(-)) atypical memory B cells and (CD19(+), CD27(+), CD38(+)) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73(+) B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either \'driver or passenger\' of hyperinflammation during COVID-19 needs to be clarified
B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27–, CD21–) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needs to be clarified

is ?:annotates of