PropertyValue
?:abstract
  • OBJECTIVE: Significant morbidity and mortality from SARS-CoV-2 has been experienced in America, Europe and Asia; whereas, the number of infections and deaths in sub-Sahara Africa (SSA) has remained comparatively low. One hypothesis is that population in SSA has been exposed to other coronaviruses prior to the COVID-19 pandemic and resulted in some degree of cross-protection against SARS-CoV-2 infection and pathogenesis. Our goal was to evaluate this hypothesis by comparing SARS-CoV-2 cross-reactive antibodies in pre-pandemic plasma samples collected from SSA and USA. METHOD: Pre-COVID-19 pandemic plasma samples from SSA and USA were collected and tested by immunofluorescence assay against the spike and nucleocapid proteins of all known human coronaviruses (HCoV). RESULTS: Significantly higher prevalence of SARS-CoV-2 serological cross-reactivity was detected in samples from SSA compared to USA. Majority of these cross-reactive samples cross-recognized SARS-CoV-2 nucleocapsid protein together with recognition of spike proteins from other HCoVs. Since nucleocapsid proteins from HCoV-NL63 and HCoV-229E were detected by majority of samples, it implicates prior exposure to these two HCoVs as the likely source for cross-reactive antibodies against SARS-CoV-2. CONCLUSION: Low SARS-CoV-2 infection and disease in SSA appears to correlate with pre-pandemic serological cross-recognition of HCoVs, which are substantially more prevalent in SSA than USA.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.ijid.2020.10.104
?:doi
?:journal
  • Int_J_Infect_Dis
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/e6b7d0c616677e75e8f2f46eb2cf421250dfdfdf.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7648883.xml.json
?:pmcid
?:pmid
?:pmid
  • 33176202.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • High prevalence of pre-existing serological cross-reactivity against SARS-CoV-2 in sub-Sahara Africa
?:type
?:year
  • 2020-11-08

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