PropertyValue
?:abstract
  • PURPOSE: The blockade of the renin–angiotensin–aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RAAS-blockers and an increased risk of cancer, particularly of lung cancer. This narrative review aims to give a critical appraisal of current evidence and to help physicians understand potential links between RAAS blockade and de novo lung cancer development. METHODS: Numerous pharmaco-epidemiologic studies, mostly retrospective cohort analyses, evaluated the association of RAAS blockade with lung cancer incidence and reported inconsistent findings. Meta-analyses could not further clarify a possible link between RAAS blockade and the risk of lung cancer. RESULTS: International regulatory agencies (FDA, EMA) have concluded that the use of RAAS blockers is not associated with an increased risk of developing lung cancer. Co-administration of RAAS blockers to systemic therapy of advanced non-small cell lung cancer seems to have positive effects on the outcome. CONCLUSION: Until more comprehensive analyses have been completed, there is no need to change clinical practise. Additional prospective randomized trials with long-term follow-up are needed to investigate the effects of these drugs on the development and progression of lung cancer.
is ?:annotates of
?:creator
?:doi
  • 10.1007/s00432-020-03445-x
?:doi
?:journal
  • J_Cancer_Res_Clin_Oncol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/46b93dd1d0e12f5f445c46ba138b5965f2c38fb1.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7684567.xml.json
?:pmcid
?:pmid
?:pmid
  • 33231730.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Risk of lung cancer and renin–angiotensin blockade: a concise review
?:type
?:year
  • 2020-11-24

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