PropertyValue
?:abstract
  • Traditionally viewed as important in the regulation of blood pressure, the renin-angiotensin system - and specifically the angiotensin-converting enzyme (ACE)-angiotensin (Ang) II-AT(1 )receptor axis - may play a prominent role to promote inflammation and fibrosis. ACE2, a new component of the renin-angiotensin system, has emerged as a key enzyme that selectively degrades Ang II and generates Ang-(1-7), a bioactive peptide with anti-inflammatory and anti-fibrotic actions. Takahashi and colleagues demonstrate circulating titers of inhibitory autoantibodies against ACE2 in patients with systemic sclerosis. The current study reveals a potentially novel mechanism to attenuate the catalytic activity of ACE2, thereby promoting the actions of Ang II.
?:creator
?:doi
  • 10.1186/ar3052
?:doi
?:externalLink
?:journal
  • Arthritis_Res_Ther
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/1a162c4dd45cad2c49168b2d6f2c350e47a3db09.json
?:pmc_json_files
  • document_parses/pmc_json/PMC2911909.xml.json
?:pmcid
?:pmid
?:pmid
  • 20602809
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation
?:type
?:year
  • 2010-06-28

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