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?:abstract
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Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step of infection for emerging coronaviruses and document that it completely prevents SARS-CoV-2 infection in ferrets. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour co-housing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and non-toxic and thus readily translate into a safe and effective intranasal prophylactic approach to reduce transmission of SARS-CoV-2.
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?:doi
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10.1101/2020.11.04.361154
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document_parses/pdf_json/9fdeb0b1b2bec5625ebdbf40887436f51f37faa7.json; document_parses/pdf_json/eaac28847351198441bf6317ad457a35e00c4e75.json; document_parses/pdf_json/b8534bfc19fae1d3c0d30300fbe68681aa65e9f9.json
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?:pmid
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?:source
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BioRxiv; Medline; PMC; WHO
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?:title
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Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets
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