PropertyValue
?:abstract
  • Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
is ?:annotates of
?:creator
?:doi
  • 10.3389/fmolb.2020.00222
?:doi
?:journal
  • Front_Mol_Biosci
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/7b37786e29c2940226079d0a1b7f868bfecc5f8c.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7533540.xml.json
?:pmcid
?:pmid
?:pmid
  • 33195401.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • SARS-CoV-2 Virion Stabilization by Zn Binding
?:type
?:year
  • 2020-09-17

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