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During the sever pandemic of coronavirus, the development and deployment of efficient disinfection technology have attracted hospitals\' attention Chlorine dioxide (ClO_2) gas has been validated as an efficient disinfector and air pollution control due its high oxidation ability This article reviewed the principles and application of ClO_2 gas on disinfection, sterilization and air pollutants abatement The principles of ClO_2 gas production, chemistry and related generator issues were discussed We also review some case studies of the application of ClO_2 gas in the medical field and food industry as a sterilizer Oxidation of nitrogen oxide (NO_x), sulfur oxide (SO_x), mercury (Hg), and volatile organic compounds (VOCs) using ClO_2 gas has been investigated The process chemistry and demonstration of applying ClO_2 gas for air pollutants oxidation and absorption have also been provided In conclusion, we suggest the future priority research direction of ClO_2 gas application are included the development of smart and robust ClO_2 gas release system, the integration of an innovative robotic technology in ClO_2 sterilization for epidemic prevention, and the evaluation of ClO_2 emissions impact on indoor air quality in hospitals
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