?:abstract
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Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Despite this promise, the antiviral activity of ivermectin has not been consistently proven in vivo While ivermectin\'s activity against SARS-CoV-2 is currently under investigation in patients, insufficient emphasis has been placed on formulation challenges Here, we discuss challenges surrounding the use of ivermectin in the context of coronavirus disease-19 (COVID-19) and how novel formulations employing micro- and nanotechnologies may address these concerns
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