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In a group of patients with microsatellite-unstable tumors, pembrolizumab led to longer progression-free survival and was less toxic than standard chemotherapy see Original Article, N Engl J Med 2020;383:2207-2218 Effect of Finerenone on Chronic Kidney Disease Outcomes In this double-blind trial, patients with chronic kidney disease and type 2 diabetes were randomly assigned to receive the nonsteroidal, selective mineralocorticoid receptor antagonist finerenone or placebo A detailed investigation identified person-to-person transmission that was driven by three symptomatic persons see Original Article, N Engl J Med 2020;383:2230-2241 Malaria Chemoprophylaxis in Sub-Saharan Africa In this randomized, placebo-controlled trial in children younger than 5 years of age with severe anemia in an area in which malaria is endemic, dihydroartemisinin–piperaquine administered after hospital discharge resulted in a lower incidence of readmission or death in the 3 months after discharge than placebo see Original Article, N Engl J Med 2020;383:2242-2254 Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and immune-cell hyperactivation, has various causes and is characterized by constitutional symptoms, systemic inflammation, and multiorgan dysfunction [ ]addressing obesity and other major health threats in concert could enable more effective solutions see Perspective, N Engl J Med 2020;383:2197-2200 The Bottom of the Health Care Rationing Iceberg Here I was, trying to do a perfect job allocating a handful of mechanical ventilators for an unprecedented viral pandemic, while every day the entire health care system fails utterly to fairly allocate all kinds of health care to an enormous number of vulnerable people see Perspective, N Engl J Med 2020;383:2200-2201 “When Will We Have a Vaccine?” People inquiring about Covid-19 vaccines often want to know when the public can be confident that available vaccines are safe and effective, when a vaccine will be available to people like them, and when uptake will be high enough to enable a return to prepandemic life see Perspective, N Engl J Med 2020;383:2202-2204 From Portraits to Role Models To become something, you must see it first — whether in the faces of those who have gone before you or in your own mind
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Issue Highlights, December 31, 2020
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Issue Highlights, March 12, 2020Oxygen Therapy for the Critically IllMeasles in New York CityAspirin and Hepatocellular CarcinomaComplications of Unsafe AbortionInterchangeable Insulins
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Issue Highlights, October 22, 2020Dasatinib–Blinatumomab in Ph-Positive ALLAnti–Siglec-8 Antibody in GastritisInhaled GM-CSF for aPAPSensory GanglionopathyEnding the Health Reform Stalemate
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