PropertyValue
?:abstract
  • OBJECTIVE: To explore the clinical value of SARS-CoV2 IgM and IgG antibodies in the diagnosis of COVID-19 in suspected cases by likelihood ratio. METHODS: By reinterpreting data from a previous study, the positive likelihood ratio of IgM and IgG antibodies in COVID-19 pneumonia diagnosis was calculated, and the posterior probability of IgM and IgG antibodies and their tandem detection was calculated finally. RESULTS: The positive likelihood ratios of single IgM and IgG antibodies were 18.50 and 12.65, respectively, and the posterior probabilities were 90.18% and 86.26%, respectively. However, the posterior probability of the two antibody-tandem test was 99.15%, which could give clinicians more quantitative confidence in the diagnosis of COVID-19 in suspected cases. According to the results of this study, combining the advantages and disadvantages of nucleic acid testing and antibody detection, a feasible clinical path was found for clinicians to diagnose COVID-19 pneumonia from suspected cases. CONCLUSION: For suspected cases, IgM- and IgG-antibody tests should first be done at the same time. If all antibody tests are positive, COVID-19 pneumonia could be confirmed. If not, nucleic acid detection (once or more) should be carried out, and in extreme cases high-throughput viral genome sequencing is required.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.2147/jir.s287733
?:journal
  • J_Inflamm_Res
?:license
  • cc-by-nc
?:pdf_json_files
  • document_parses/pdf_json/24d32863e953a2b9429bf307e8084af5f5de72ae.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7735789.xml.json
?:pmcid
?:pmid
?:pmid
  • 33328754.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Clinical Value of SARS-CoV2 IgM and IgG Antibodies in Diagnosis of COVID-19 in Suspected Cases
?:type
?:year
  • 2020-12-10

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