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?:abstract
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BACKGROUND The purpose of this study is to evaluate serum Pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. MATERIALS AND METHODS This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 2020 and August 15 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. RESULTS Of 88 patients with COVID-19, 59 (67%) were discharged with complete cure and 29 (33%) resulted in death. 46 (52.3%) of the patients were men. PTX-3 median value [IQR] was 3.66 ng/mL (0.9-27.9) in all patients, 3.3 ng/mL (0.9-27.9) in survivors and 3.91 ng/mL (1.9-23.2) in non-survivors which was significantly higher (p= 0.045). As a receiver operating characteristic curve analysis the cut-off value of PTX-3 for predicting mortality in patients was 3.73 with 65% sensitivity and 65% specificity (AUC: 0.646, 95% CI: 0.525-0.767, P= 0.045). Also, we found significant cut-off values with respect to D-Dimer, D-Dimer/ PTX-3, high-sensitivity troponin, high-sensitivity troponin/ PTX-3, lymphocyte, PTX-3/ lymphocyte, procalcitonin, procalcitonin/ PTX-3, CRP, and CRP/ PTX-3 (P<0.05). CONCLUSION In this study, as far as we know, for the first time, we have shown PTX-3 as the new mortality biomarker for COVID-19 disease.
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