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Abstract Objective To investigate psychological state of hospitalized cancer patients undergoing radiation therapy and evaluate effects of customized psychological intervention on patients\' psychological state during novel Coronavirus (COVID-19) outbreak Method Fifty-eight hospitalized head and neck cancer patients undergoing radiation therapy were included and received online and offline psychological intervention General information questionnaire and the Self-Report Symptom Inventory, Symptom Check-List90 (SCL-90) were utilized to investigate and analyze psychological state of hospitalized head and neck cancer patients undergoing radiation therapy before and after intervention Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) were used to evaluate depression severity and anxiety severity of them Results Overall psychological state of patients (include nine symptom dimensions: somatization, obsessive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism) was improved significantly after intervention (P?<? 05) Moreover, scores of SAS and SDS were lowered Conclusion Customized psychological intervention helped to improve overall psychological state of hospitalized cancer patients undergoing radiation therapy during COVID-19 outbreak and showed encouraging effects on reduction severity of depression and anxiety
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