PropertyValue
?:abstract
  • The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has elicited an equally rapid response aiming to develop a COVID-19 vaccine. These efforts are encouraging; however, comprehensive efficacy and safety evaluations are essential in the development of a vaccine, and we can learn from previous vaccine development campaigns. In this Perspective, we summarize examples of vaccine-associated disease enhancement in the history of developing vaccines against respiratory syncytial virus, dengue virus, SARS-CoV and Middle East respiratory syndrome coronavirus, which highlight the importance of a robust safety and efficacy profile, and present recommendations for preclinical and clinical evaluation of COVID-19 vaccine candidates as well as for vaccine design and optimization.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1038/s41579-020-00462-y
?:journal
  • Nat_Rev_Microbiol
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/77b857067dafa3d813170004d2be714bdc8ef438.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7566580.xml.json
?:pmcid
?:pmid
?:pmid
  • 33067570.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Learning from the past: development of safe and effective COVID-19 vaccines
?:type
?:year
  • 2020-10-16

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