uh7t91qd

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?:abstract	BACKGROUND: Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. METHODS: We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1–May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission. RESULTS: A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index < 60 were 30.8%, 25.6%, 30.5%, and 21.0%, respectively. The overall case-fatality rate was 46.9% (n: 1301) and increased with age (80–84 years: 41.6%; 85–90 years: 47.3%; 90–94 years: 52.7%; ≥95 years: 54.2%). After analysis, male sex and moderate-to-severe dependence were independently associated with in-hospital mortality; comorbidities were not predictive. At admission, independent risk factors for death were: oxygen saturation < 90%; temperature ≥ 37.8°C; quick sequential organ failure assessment (qSOFA) score ≥ 2; and unilateral–bilateral infiltrates on chest x-rays. Some analytical findings were independent risk factors for death, including estimated glomerular filtration rate < 45 mL/min/1.73 m(2); lactate dehydrogenase ≥ 500 U/L; C-reactive protein ≥ 80 mg/L; neutrophils ≥ 7.5 × 10(3)/μL; lymphocytes < 0.8 × 10(3)/μL; and monocytes < 0.5 × 10(3)/μL. CONCLUSIONS: This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status—not comorbidities—are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.
?:creator	<https://research.tib.eu/covid-19/entity/Ramos-Rincon%2C_Jose-Manuel%3B_Buonaiuto%2C_Ver%C3%B3nica%3B_Ricci%2C_Michele%3B_Mart%C3%ADn-Carmona%2C_Jesica%3B_Paredes-Ru%C3%ADz%2C_Diana%3B_Calder%C3%B3n-Moreno%2C_Mar%C3%ADa%3B_Rubio-Rivas%2C_Manel%3B_Beato-P%C3%A9rez%2C_Jos%C3%A9-Luis%3B_Arnalich-Fern%C3%A1ndez%2C_Francisco%3B_Monge-Monge%2C_Daniel%3B_Vargas-N%C3%BA%C3%B1ez%2C_Juan-Antonio%3B_Acebes-Repiso%2C_Gonzalo%3B_Mendez-Bailon%2C_Manuel%3B_Perales-Fraile%2C_Isabel%3B_Garc%C3%ADa-Garc%C3%ADa%2C_Gema-Mar%C3%ADa%3B_Guisado-Vasco%2C_Pablo%3B_Abdelhady-Kishta%2C_Alaaeldeen%3B_Pascual-P%C3%A9rez%2C_Maria-de-los-Reyes%3B_Rodr%C3%ADguez-Fern%C3%A1ndez-Viagas%2C_Cristina%3B_Monta%C3%B1o-Mart%C3%ADnez%2C_Adri%C3%A1n%3B_L%C3%B3pez-Ruiz%2C_Antonio%3B_Gonzalez-Juarez%2C_Maria-Jesus%3B_P%C3%A9rez-Garc%C3%ADa%2C_Cristina%3B_Casas-Rojo%2C_Jos%C3%A9-Manuel%3B_G%C3%B3mez-Huelgas%2C_Ricardo>
?:doi	<https://research.tib.eu/covid-19/entity/10.1093/gerona/glaa243>
?:doi	10.1093/gerona/glaa243
?:journal	J_Gerontol_A_Biol_Sci_Med_Sci
?:license	no-cc
?:pdf_json_files	document_parses/pdf_json/7e74f02ffca601085f6b1bb50f80bdb013d0855f.json
?:pmc_json_files	document_parses/pmc_json/PMC7797762.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7797762>
?:pmid	<https://research.tib.eu/covid-19/entity/33103720.0>
?:pmid	33103720.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/7e74f02ffca601085f6b1bb50f80bdb013d0855f>
?:source	Medline; PMC
?:title	Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-10-26

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Value

?:abstract

BACKGROUND: Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with COVID-19. This study aims to describe the clinical characteristics of very old inpatients with COVID-19 and identify risk factors for in-hospital mortality at admission. METHODS: We conducted a nationwide, multicenter, retrospective, observational study in patients ≥ 80 years hospitalized with COVID-19 in 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1–May 29, 2020). The primary outcome was in-hospital mortality. A uni- and multivariate logistic regression was performed to assess predictors of mortality at admission. RESULTS: A total of 2772 consecutive patients (49.4% men, median age 86.3 years) were analyzed. Rates of atherosclerotic cardiovascular disease, diabetes mellitus, dementia, and Barthel Index < 60 were 30.8%, 25.6%, 30.5%, and 21.0%, respectively. The overall case-fatality rate was 46.9% (n: 1301) and increased with age (80–84 years: 41.6%; 85–90 years: 47.3%; 90–94 years: 52.7%; ≥95 years: 54.2%). After analysis, male sex and moderate-to-severe dependence were independently associated with in-hospital mortality; comorbidities were not predictive. At admission, independent risk factors for death were: oxygen saturation < 90%; temperature ≥ 37.8°C; quick sequential organ failure assessment (qSOFA) score ≥ 2; and unilateral–bilateral infiltrates on chest x-rays. Some analytical findings were independent risk factors for death, including estimated glomerular filtration rate < 45 mL/min/1.73 m(2); lactate dehydrogenase ≥ 500 U/L; C-reactive protein ≥ 80 mg/L; neutrophils ≥ 7.5 × 10(3)/μL; lymphocytes < 0.8 × 10(3)/μL; and monocytes < 0.5 × 10(3)/μL. CONCLUSIONS: This first large, multicenter cohort of very old inpatients with COVID-19 shows that age, male sex, and poor preadmission functional status—not comorbidities—are independently associated with in-hospital mortality. Severe COVID-19 at admission is related to poor prognosis.

?:creator