PropertyValue
?:abstract
  • Currently, there is no specific antiviral treatment for COVID-19 However, drugs previously developed to treat other viral infections are being tested to verify if they might also be effective against SARS-CoV-2, the virus that causes COVID-19 Twenty years ago, the F D A approved Lopinavir/ritonavir (LPV/r) to treat HIV infection LPV and ritonavir were initially purposed to inhibit 3-chymotrypsin-like protease (3CLpro) of SARS-CoV and MERS-CoV and preliminary promising data on its efficacy for treating people infected with those viruses were available Therefore, due to the high genetic similarities among those viruses and SARS-CoV-2, early during COVID-19 pandemic LPV/r was also proposed as one emergency treatment We reviewed data from the literature about LPV/r treatment and SARS-CoV-2 infection, mainly focused on the efficacy and safety of this drugs for COVID-19 treatment We can conclude that although up to date no clear benefit has been observed with the LPV/r treatment beyond standard care, its efficacy against SARS-COV-2 infection deserves further evaluations, particularly during the very early phase of the disease
is ?:annotates of
?:creator
?:journal
  • Biomedical_Journal
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Lopinavir/ritonavir: repurposing an old drug for HIV infection in COVID-19 treatment
?:type
?:who_covidence_id
  • #917222
?:year
  • 2020

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