uyxe59xy

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?:abstract	OBJECTIVE To report clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurologic diseases with and without COVID-19. METHODS In this retrospective, single center cohort study, we included all adult inpatients with confirmed COVID-19, admitted to a Neuro-COVID Unit from February 21, 2020, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records and compared (FDR-corrected) to those of neurologic patients without COVID-19 admitted in the same period. RESULTS One hundred seventy-three patients were included in this study, of whom 56 were positive for COVID-19 while 117 were negative for COVID-19. Patients with COVID-19 were older (77.0, IQR 67.0-83.8 vs 70.1, IQR 52.9-78.6, p = 0.006), had a different distribution regarding admission diagnoses, including cerebrovascular disorders (n = 43, 76.8% vs n = 68, 58.1%), and had a higher quick Sequential Organ Failure Assessment (qSOFA) score on admission (0.5, IQR 0.4-0.6 vs 0.9, IQR 0.7-1.1, p = 0.006). In-hospital mortality rates (n = 21, 37.5% vs n = 5, 4.3%, p < 0.001) and incident delirium (n = 15, 26.8% vs n = 9, 7.7%, p = 0.003) were significantly higher in the COVID-19 group. COVID-19 and non-COVID patients with stroke had similar baseline characteristics but patients with COVID-19 had higher modified Rankin scale scores at discharge (5.0, IQR 2.0-6.0 vs 2.0, IQR 1.0-3.0, p < 0.001), with a significantly lower number of patients with a good outcome (n = 11, 25.6% vs n = 48, 70.6%, p < 0.001). In patients with COVID-19, multivariable regressions showed increasing odds of in-hospital death associated with higher qSOFA scores (OR 4.47, 95% CI 1.21-16.5; p = 0.025), lower platelet count (0.98, 0.97-0.99; p = 0.005) and higher lactate dehydrogenase (1.01, 1.00-1.03; p = 0.009) on admission. CONCLUSIONS COVID-19 patients admitted with neurologic disease, including stroke, have a significantly higher in-hospital mortality, incident delirium and higher disability than patients without COVID-19.
?:creator	<https://research.tib.eu/covid-19/entity/Benussi%2C_Alberto%3B_Pilotto%2C_Andrea%3B_Premi%2C_Enrico%3B_Libri%2C_Ilenia%3B_Giunta%2C_Marcello%3B_Agosti%2C_Chiara%3B_Alberici%2C_Antonella%3B_Baldelli%2C_Enrico%3B_Benini%2C_Matteo%3B_Bonacina%2C_Sonia%3B_Brambilla%2C_Laura%3B_Caratozzolo%2C_Salvatore%3B_Cortinovis%2C_Matteo%3B_Costa%2C_Angelo%3B_Piccinelli%2C_Stefano_Cotti%3B_Cottini%2C_Elisabetta%3B_Cristillo%2C_Viviana%3B_Delrio%2C_Ilenia%3B_Filosto%2C_Massimiliano%3B_Gamba%2C_Massimo%3B_Gazzina%2C_Stefano%3B_Gilberti%2C_Nicola%3B_Gipponi%2C_Stefano%3B_Imarisio%2C_Alberto%3B_Invernizzi%2C_Paolo%3B_Leggio%2C_Ugo%3B_Leonardi%2C_Matilde%3B_Liberini%2C_Paolo%3B_Locatelli%2C_Martina%3B_Masciocchi%2C_Stefano%3B_Poli%2C_Loris%3B_Rao%2C_Renata%3B_Risi%2C_Barbara%3B_Rozzini%2C_Luca%3B_Scalvini%2C_Andrea%3B_Schiano_di_Cola%2C_Francesca%3B_Spezi%2C_Raffaella%3B_Vergani%2C_Veronica%3B_Volonghi%2C_Irene%3B_Zoppi%2C_Nicola%3B_Borroni%2C_Barbara%3B_Magoni%2C_Mauro%3B_Pezzini%2C_Alessandro%3B_Padovani%2C_Alessandro>
?:doi	10.1212/wnl.0000000000009848
?:doi	<https://research.tib.eu/covid-19/entity/10.1212/wnl.0000000000009848>
?:journal	Neurology
?:license	unk
?:pmid	<https://research.tib.eu/covid-19/entity/32444493>
?:pmid	32444493
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	Medline
?:title	Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy.
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-05-22

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Value

?:abstract

OBJECTIVE To report clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurologic diseases with and without COVID-19. METHODS In this retrospective, single center cohort study, we included all adult inpatients with confirmed COVID-19, admitted to a Neuro-COVID Unit from February 21, 2020, who had been discharged or died by April 5, 2020. Demographic, clinical, treatment, and laboratory data were extracted from medical records and compared (FDR-corrected) to those of neurologic patients without COVID-19 admitted in the same period. RESULTS One hundred seventy-three patients were included in this study, of whom 56 were positive for COVID-19 while 117 were negative for COVID-19. Patients with COVID-19 were older (77.0, IQR 67.0-83.8 vs 70.1, IQR 52.9-78.6, p = 0.006), had a different distribution regarding admission diagnoses, including cerebrovascular disorders (n = 43, 76.8% vs n = 68, 58.1%), and had a higher quick Sequential Organ Failure Assessment (qSOFA) score on admission (0.5, IQR 0.4-0.6 vs 0.9, IQR 0.7-1.1, p = 0.006). In-hospital mortality rates (n = 21, 37.5% vs n = 5, 4.3%, p < 0.001) and incident delirium (n = 15, 26.8% vs n = 9, 7.7%, p = 0.003) were significantly higher in the COVID-19 group. COVID-19 and non-COVID patients with stroke had similar baseline characteristics but patients with COVID-19 had higher modified Rankin scale scores at discharge (5.0, IQR 2.0-6.0 vs 2.0, IQR 1.0-3.0, p < 0.001), with a significantly lower number of patients with a good outcome (n = 11, 25.6% vs n = 48, 70.6%, p < 0.001). In patients with COVID-19, multivariable regressions showed increasing odds of in-hospital death associated with higher qSOFA scores (OR 4.47, 95% CI 1.21-16.5; p = 0.025), lower platelet count (0.98, 0.97-0.99; p = 0.005) and higher lactate dehydrogenase (1.01, 1.00-1.03; p = 0.009) on admission. CONCLUSIONS COVID-19 patients admitted with neurologic disease, including stroke, have a significantly higher in-hospital mortality, incident delirium and higher disability than patients without COVID-19.

?:creator