PropertyValue
?:abstract
  • [Image: see text] Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inhibiting the interaction between the envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 is a potential antiviral therapeutic approach, but little is known about how dietary compounds interact with ACE2. The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3′,4′-hydroxylation inhibit recombinant human (rh)ACE2 activity. rhACE2 activity was assessed with the fluorogenic substrate Mca-APK(Dnp). Polyphenols reduced rhACE2 activity by 15–66% at 10 μM. Rutin, quercetin-3-O-glucoside, tamarixetin, and 3,4-dihydroxyphenylacetic acid inhibited rhACE2 activity by 42–48%. Quercetin was the most potent rhACE2 inhibitor among the polyphenols tested, with an IC(50) of 4.48 μM. Thus, quercetin, its metabolites, and polyphenols with 3′,4′-hydroxylation inhibited rhACE2 activity at physiologically relevant concentrations in vitro.
is ?:annotates of
?:creator
?:doi
  • 10.1021/acs.jafc.0c05064
?:doi
?:journal
  • J_Agric_Food_Chem
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/f9b3393967d626a28b9bcd3bca9b11a0d59fd3c1.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7687294.xml.json
?:pmcid
?:pmid
?:pmid
  • 33179911.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity
?:type
?:year
  • 2020-11-12

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