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Objectives: Each year more than two million Muslims from 185 countries gather in Mecca for the pilgrimage Respiratory viral infections are the most common diseases that occur during the Hajj The aim of this study was to examine Iranian pilgrims with severe acute respiratory infections (SARI) returning from Hajj in 2015 and 2017, with particular attention paid to the detection of human rhinovirus (HRV), human respiratory syncytial virus (HRSV), and Middle East respiratory syndrome coronavirus (MERS-CoV) Method(s): A total of 451 throat swabs collected from pilgrims with SARI but negative for influenza viruses were tested for HRV, HRSV, and MERS-CoV in 2015 and 2017 RT-PCR was used for MERS-CoV and HRSV detection and conventional nested RT-PCR for HRV detection Result(s): None of the cases had MERS-CoV but HRV was detected in 8 4% (38/451) patients, 5 6% (19/338) in 2015, and 16 8% (19/113) in 2017 A single case of HRSV was detected in 2015 (1/338) Conclusion(s): The study showed HRV to be the most common infection The test results contributed towards continuing surveillance efforts, infection control, and comprehensive planning and the process should be replicated for other respiratory viruses in pilgrims
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