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INTRODUCTION: We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS‐CoV‐2 infection. METHODS: Cytologic findings in cases under investigation of SARS‐CoV‐2 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSCoV‐2 RT‐PCR determination were performed to detect virus. RESULTS: No viral inclusions were noted in squamous cells obtained from virus transport medium. Immunohistochemestry with monoclonal antibodody against SARS‐CoV‐2 viral nucleoprotein was present in squamous cells. No positivity was present in others cellular components. CONCLUSIONS: SARS‐CoV‐2 predominantly localizes squamous cells in cytology samples of patients with RT‐PCR positive determination of SARSCoV‐2. The results of the current study support the notion that the nasopharyngeal region is the anatomical station that SARS‐CoV‐2 infects first, and the infection can lead to the migration of the virus into the lower airways.
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document_parses/pdf_json/2bf548db88f4c4c4e69bb57f9cd7339492f651c5.json
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Liquid‐based cytological and immunohistochemical study of nasopharyngeal swab from persons under investigation for SARS‐CoV‐2 infection
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