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?:abstract
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OBJECTIVE: To explore the clinical value of SARS-CoV2 IgM and IgG antibodies in the diagnosis of COVID-19 in suspected cases by likelihood ratio METHODS: By reinterpreting data from a previous study, the positive likelihood ratio of IgM and IgG antibodies in COVID-19 pneumonia diagnosis was calculated, and the posterior probability of IgM and IgG antibodies and their tandem detection was calculated finally RESULTS: The positive likelihood ratios of single IgM and IgG antibodies were 18 50 and 12 65, respectively, and the posterior probabilities were 90 18% and 86 26%, respectively However, the posterior probability of the two antibody-tandem test was 99 15%, which could give clinicians more quantitative confidence in the diagnosis of COVID-19 in suspected cases According to the results of this study, combining the advantages and disadvantages of nucleic acid testing and antibody detection, a feasible clinical path was found for clinicians to diagnose COVID-19 pneumonia from suspected cases CONCLUSION: For suspected cases, IgM- and IgG-antibody tests should first be done at the same time If all antibody tests are positive, COVID-19 pneumonia could be confirmed If not, nucleic acid detection (once or more) should be carried out, and in extreme cases high-throughput viral genome sequencing is required
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