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?:abstract
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Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4(+) T cells and CD8(+) T cells declined with a half-life of 3–5 months. By studying antibody, memory B cell, CD4(+) T cell, and CD8(+) T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.
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?:creator
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?:doi
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?:doi
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10.1101/2020.11.15.383323
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?:license
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?:pdf_json_files
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document_parses/pdf_json/ca4a8aaee4457c2ba314039e5cd543f02b0c571f.json; document_parses/pdf_json/577ede5451785ebd335f5b108e417a2a74b6c3e7.json
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document_parses/pmc_json/PMC7805444.xml.json
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?:pmid
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?:sha_id
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?:source
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BioRxiv; Medline; PMC; WHO
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?:title
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Immunological memory to SARS-CoV-2 assessed for up to eight months after infection
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?:year
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