PropertyValue
?:abstract
  • The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
is ?:annotates of
?:creator
?:journal
  • Trends_biochem._sci
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Nucleic Acid-Based Technologies Targeting Coronaviruses
?:type
?:who_covidence_id
  • #947467
?:year
  • 2020

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