| Property | Value |
|---|
|
?:abstract
|
-
BACKGROUND AND PURPOSE Neurological complications of SARS-CoV-2 infection are noticed among critically-ill patients soon after disease onset. Information on delayed neurological sequelae of SARS-CoV-2 infection is nil. Following a longitudinal study design, we assessed the occurrence of cognitive decline among individuals with a history of mild symptomatic SARS-CoV-2 infection. METHODS Stroke- and seizure-free Atahualpa residents aged ≥40 years who had pre-pandemic cognitive assessments as well as normal brain MRI and EEG recordings, underwent repeated evaluations six months after a SARS-CoV-2 outbreak infection in Atahualpa. Patients requiring oxygen therapy, hospitalization, and those who had initial neurological manifestations were excluded. Cognitive decline was defined as a reduction in Montreal Cognitive Assessment (MoCA) score between the post-pandemic and pre-pandemic assessments that was ≥4 points than the reduction observed between two pre-pandemic MoCAs. The relationship between SARS-CoV-2 infection and cognitive decline was assessed by fitting logistic mixed models for longitudinal data as well as exposure-effect models. RESULTS Of 93 included individuals (mean age: 62.6±11 years), 52 (56%) had a history of mild symptomatic SARS-CoV-2 infection. Post-pandemic MoCA decay was worse in seropositive individuals. Cognitive decline was recognized in 11/52 (21%) seropositive and 1/41 (2%) seronegative individuals. In multivariate analyses, the odds for developing cognitive decline was 18.1 times higher among SARS-CoV-2 seropositive individuals (95% C.I.: 1.75 - 188; p=0.015). Exposure-effects models confirmed this association (β: 0.24; 95% C.I.: 0.07 - 0.41; p=0.006). CONCLUSIONS This study provides evidence of cognitive decline among individuals with mild symptomatic SARS-CoV-2 infection. The pathogenesis of this complication remains unknown.
|
|
?:creator
|
|
|
?:doi
|
|
|
?:doi
|
|
|
?:journal
|
-
European_journal_of_neurology
|
|
?:license
|
|
|
?:pmid
|
|
|
?:pmid
|
|
|
?:publication_isRelatedTo_Disease
|
|
|
?:source
|
|
|
?:title
|
-
Cognitive decline among individuals with history of mild symptomatic SARS-CoV-2 infection. A longitudinal prospective study nested to a population cohort.
|
|
?:type
|
|
|
?:year
|
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}