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Background: To delineate the clinical characteristics associated with long-term viral shedding (>21 days) in patients with coronavirus disease 2019 (COVID-19) Methods: In this retrospective study, factors associated with long-term (>21 days) severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA shedding were evaluated in a conhort of 609 patients from two hospitals in Wuhan Results: The median duration of SARS-CoV-2 viral shedding was 19 days (interquartile range, 10-28 days) among all patients There were 42% of patients having prolonged viral shedding time (>21 days), in which the longest viral shedding time was 58 days When comparing patients with early (≤21 days) and late viral RNA clearance (>21 days), prolonged viral shedding was associated with age 21 days) is not a rare phenomenon among COVID-19 infectious patients Age range (<65) and female sex are independent risk factors for long-term viral shedding Early antiviral treatment should be considered for COVID-19 patients with such risk factors Further study should be conducted to know the infectivity of patients with long-term viral shedding in order to develop reasonable control measures
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American_Journal_of_Translational_Research
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Clinical characteristics associated with long-term viral shedding in patients with coronavirus disease 2019
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