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Two pandemics of respiratory distress diseases associated with introductions of the species Severe acute respiratory syndrome-related coronavirus in the human population during 21st century raised unprecedented interest in coronavirus research and assigned it unseen urgency. Two viruses responsible for the outbreaks, SARS-CoV and SARS-CoV-2, are in the spotlight and the focus of the current fast-paced research. It is based on the foundation laid down by studies of many corona- and related viruses that collectively form the vast order Nidovirales. Comparative genomics of nidoviruses played a key role in this advancement over more than 30 years. It facilitated transfer of knowledge from characterized to newly identified viruses, like SARS-CoV and SARS-CoV-2, as well as contributed to dissection of the nidovirus proteome and identification of patterns of variations between different taxonomic groups, from species to families. This review revisits selected cases of protein conservation and variation that define nidoviruses, illustrates remarkable plasticity of the proteome during nidovirus adaptation, and asks questions at the interface of the proteome and processes that are vital for nidovirus reproduction and could inform the ongoing research of SARS-CoV-2.
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10.1016/j.bbrc.2020.11.015
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Biochem_Biophys_Res_Commun
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document_parses/pdf_json/6b84c10205443dd682fd2b871b41200e1162d9b1.json
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document_parses/pmc_json/PMC7664520.xml.json
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?:title
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A nidovirus perspective on SARS-CoV-2
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