PropertyValue
?:abstract
  • While T cells are considered to play a primary role in IgE-mediated atopic diseases, little is known about the systemic variations of T cell subsets from patients with allergic rhinitis (AR). To elucidate the characteristics of peripheral T cells, we analyzed natural killer, B cell, and T cell populations, performed T cell subset construction, and assessed chemokine receptor and associated serum cytokine expression in 25 AR patients and 20 healthy controls. Our results revealed increased levels of CD4(+)T cells, serum interleukin (IL)-10, IL-6, and interferon (IFN)-γ, and reduced Th1 and Th17 subsets, identified by their chemokine receptors, in AR patients. These results suggest a systemic activation of T cell responses in AR. We further demonstrated that AR patients exhibit significantly reduced CD4(+)T cell CXCR3 expression, especially in patients with moderate-severe disease severity, demonstrating that CXCR3 is a potential key molecule that hinders the Th1/Th2 balance in AR pathology. Overall, systemic T cell activation occurred in AR patients and CXCR3 dramatically decreased in CD4(+)T cells, which may ultimately be used as a potential disease and/or therapeutic target.
is ?:annotates of
?:creator
?:doi
  • 10.3389/fimmu.2020.581180
?:doi
?:externalLink
?:journal
  • Front_Immunol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/903103aba67d77d64a7a83058468749a272e7cd0.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7669911.xml.json
?:pmcid
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • PMC
?:title
  • Reduced CD4(+)T Cell CXCR3 Expression in Patients With Allergic Rhinitis
?:type
?:year
  • 2020-11-03

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