wdwstiec

Property	Value
?:abstract	Objective To understand the frequency, profile, and duration of persistent symptoms of covid-19 and to update this understanding as new evidence emerges. Design: A living systematic review produced in response to the rapidly evolving evidence base for long covid. Data sources Medline and CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on covid-19, LitCOVID, and Google Scholar to 28th September 2020. Study selection Studies reporting long-term symptoms and complications among people with confirmed or suspected covid-19, both in those previously hospitalised and those never hospitalised. Only studies incorporating over 100 participants qualified for data extraction and were assessed for risk of bias. Results were analysed using descriptive statistics. Quality assessment Risk of bias was assessed using a quality assessment checklist for prevalence studies. Results Twenty-eight studies qualified for data extraction; 16 of these were cohort studies, ten cross-sectional, and two large case series. The analysis included 9,442 adults with covid-19 from 13 countries. The longest mean follow-up period was 111 (SD: 11) days post-hospital discharge. A wide range of systemic, cardiopulmonary, gastrointestinal, neurological, and psychosocial symptoms was reported, of which the most common were breathlessness, fatigue, smell and taste disturbance, and anxiety. Persistent symptoms were described across both previously hospitalised and non-hospitalised populations. The quality of evidence was low, with a high risk of bias and heterogeneity in prevalence. The incorporated studies demonstrated limited external validity, a lack of control subjects, and inconsistent data collection methods. Few studies were conducted in primary care, no studies focused solely on children, and no studies were set in low- and middle-income countries. Conclusion: Our findings suggest that long covid is a complex, heterogeneous condition; however, the limited evidence base currently precludes a precise definition of its symptoms and prevalence. There is a clear need for robust, controlled, prospective cohort studies, including different at-risk populations and settings, incorporating appropriate investigations, collected and recorded in a standardised way.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C0002055> <https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C0003467> <https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C0009566> <https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C0013404> <https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C0015672> <https://research.tib.eu/covid-19/entity/wdwstiec_hasAnnotation_C1457887>
?:creator	<https://research.tib.eu/covid-19/entity/Michelen%2C_M.%3B_Manoharan%2C_L.%3B_Elkheir%2C_N.%3B_Cheng%2C_V.%3B_Dagens%2C_D.%3B_Hastie%2C_C.%3B_O%27Hara%2C_M.%3B_Suett%2C_J.%3B_Burls%2C_A.%3B_Foote%2C_C.%3B_Carson%2C_G.%3B_Olliaro%2C_P._L.%3B_Sigfrid%2C_L.%3B_Stavropoulou%2C_C.>
?:doi	<https://research.tib.eu/covid-19/entity/10.1101/2020.12.08.20246025>
?:doi	10.1101/2020.12.08.20246025
?:license	medrxiv
?:pdf_json_files	document_parses/pdf_json/e2c888f593ef535c352251531a2cf70a4a165863.json
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:sha_id	<https://research.tib.eu/covid-19/entity/e2c888f593ef535c352251531a2cf70a4a165863>
?:source	MedRxiv; WHO
?:title	Characterising long-term covid-19: a rapid living systematic review
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2020-12-09

Property

Value

?:abstract

Objective To understand the frequency, profile, and duration of persistent symptoms of covid-19 and to update this understanding as new evidence emerges. Design: A living systematic review produced in response to the rapidly evolving evidence base for long covid. Data sources Medline and CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on covid-19, LitCOVID, and Google Scholar to 28th September 2020. Study selection Studies reporting long-term symptoms and complications among people with confirmed or suspected covid-19, both in those previously hospitalised and those never hospitalised. Only studies incorporating over 100 participants qualified for data extraction and were assessed for risk of bias. Results were analysed using descriptive statistics. Quality assessment Risk of bias was assessed using a quality assessment checklist for prevalence studies. Results Twenty-eight studies qualified for data extraction; 16 of these were cohort studies, ten cross-sectional, and two large case series. The analysis included 9,442 adults with covid-19 from 13 countries. The longest mean follow-up period was 111 (SD: 11) days post-hospital discharge. A wide range of systemic, cardiopulmonary, gastrointestinal, neurological, and psychosocial symptoms was reported, of which the most common were breathlessness, fatigue, smell and taste disturbance, and anxiety. Persistent symptoms were described across both previously hospitalised and non-hospitalised populations. The quality of evidence was low, with a high risk of bias and heterogeneity in prevalence. The incorporated studies demonstrated limited external validity, a lack of control subjects, and inconsistent data collection methods. Few studies were conducted in primary care, no studies focused solely on children, and no studies were set in low- and middle-income countries. Conclusion: Our findings suggest that long covid is a complex, heterogeneous condition; however, the limited evidence base currently precludes a precise definition of its symptoms and prevalence. There is a clear need for robust, controlled, prospective cohort studies, including different at-risk populations and settings, incorporating appropriate investigations, collected and recorded in a standardised way.

is ?:annotates of