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SARS-CoV-2 (Covid-19) infection has recently become a worldwide challenge with dramatic global economic and health consequences As the pandemic is still spreading, new data concerning Covid-19 complications and related mechanisms become increasingly available Accumulating data suggest that the incidence of cardiac arrest and its outcome are adversely affected during the Covid-19 period This may be further exacerbated by drug-related cardiac toxicity of Covid-19 treatment regimens Elucidating the underlying mechanisms that lead to Covid-19 associated cardiac arrest is imperative, not only in order to improve its effective management but also to maximize preventive measures Herein we discuss available epidemiological data on cardiac arrest during the Covid-19 pandemic as well as possible associated causes and pathophysiological mechanisms and highlight gaps in evidence warranting further investigation The risk of transmission during cardiopulmonary resuscitation (CPR) is also discussed in this review Finally, we summarize currently recommended guidelines on CPR for Covid-19 patients including CPR in patients with cardiac arrest due to suspected drug-related cardiac toxicity in an effort to underscore the most important common points and discuss discrepancies proposed by established international societies
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Food_and_Chemical_Toxicology
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Cardiac arrest and drug-related cardiac toxicity in the COVID-19 era. Epidemiology, pathophysiology and management. (Special Issue: COVID-19 and treatments: particular emphasis on potential toxic effects.)
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