x7s413ed

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?:abstract	CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection Here, we utilized SARS-CoV-2-reactive CD4+ T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity SARS-CoV-2-reactive CD4+ memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs SARS-CoV-2-reactive CD4+ T cells from COVID-19 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies Our findings identify low-avidity CD4+ T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-reactive CD4+ T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity. SARS-CoV-2-reactive CD4+ memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs. SARS-CoV-2-reactive CD4+ T cells from COVID-19 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed. In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies. Our findings identify low-avidity CD4+ T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/x7s413ed_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Bacher%2C_P.%3B_Rosati%2C_E.%3B_Esser%2C_D.%3B_Martini%2C_G._R.%3B_Saggau%2C_C.%3B_Schiminsky%2C_E.%3B_Dargvainiene%2C_J.%3B_Schroder%2C_I.%3B_Wieters%2C_I.%3B_Khodamoradi%2C_Y.%3B_Eberhardt%2C_F.%3B_Vehreschild%2C_Mjgt_Neb_H.%3B_Sonntagbauer%2C_M.%3B_Conrad%2C_C.%3B_Tran%2C_F.%3B_Rosenstiel%2C_P.%3B_Markewitz%2C_R.%3B_Wandinger%2C_K._P.%3B_Augustin%2C_M.%3B_Rybniker%2C_J.%3B_Kochanek%2C_M.%3B_Leypoldt%2C_F.%3B_Cornely%2C_O._A.%3B_Koehler%2C_P.%3B_Franke%2C_A.%3B_Scheffold%2C_A.> <https://research.tib.eu/covid-19/entity/Bacher%2C_Petra%3B_Rosati%2C_Elisa%3B_Esser%2C_Daniela%3B_Martini%2C_Gabriela_Rios%3B_Saggau%2C_Carina%3B_Schiminsky%2C_Esther%3B_Dargvainiene%2C_Justina%3B_Schr%C3%B6der%2C_Ina%3B_Wieters%2C_Imke%3B_Khodamoradi%2C_Yascha%3B_Eberhardt%2C_Fabian%3B_Vehreschild%2C_Maria_J_G_T%3B_Neb%2C_Holger%3B_Sonntagbauer%2C_Michael%3B_Conrad%2C_Claudio%3B_Tran%2C_Florian%3B_Rosenstiel%2C_Philip%3B_Markewitz%2C_Robert%3B_Wandinger%2C_Klaus-Peter%3B_Augustin%2C_Max%3B_Rybniker%2C_Jan%3B_Kochanek%2C_Matthias%3B_Leypoldt%2C_Frank%3B_Cornely%2C_Oliver_A%3B_Koehler%2C_Philipp%3B_Franke%2C_Andre%3B_Scheffold%2C_Alexander>
?:journal	Immunity
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	WHO
?:title	Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#943206 #988080
?:year	2020

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Value

?:abstract

CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection Here, we utilized SARS-CoV-2-reactive CD4+ T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity SARS-CoV-2-reactive CD4+ memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs SARS-CoV-2-reactive CD4+ T cells from COVID-19 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies Our findings identify low-avidity CD4+ T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection
CD4+ T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and these are suggested to arise in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-reactive CD4+ T cell enrichment to examine the antigen avidity and clonality of these cells, as well as the relative contribution of CCCoV cross-reactivity. SARS-CoV-2-reactive CD4+ memory T cells were present in virtually all unexposed individuals examined, displaying low functional avidity and multiple, highly variable cross-reactivities that were not restricted to CCCoVs. SARS-CoV-2-reactive CD4+ T cells from COVID-19 patients lacked cross-reactivity to CCCoVs, irrespective of strong memory T cell responses against CCCoV in all donors analyzed. In severe but not mild COVID-19, SARS-CoV-2-specific T cells displayed low functional avidity and clonality, despite increased frequencies. Our findings identify low-avidity CD4+ T cell responses as a hallmark of severe COVID-19 and argue against a protective role for CCCoV-reactive T cells in SARS-CoV-2 infection.

is ?:annotates of