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OBJECTIVE Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients also have abnormal D-dimer concentration in the serum, but the results are controversial. METHOD A meta-analysis first aims to explored the possible clinical severe between D-dimer concentration and COVID-19, and analysis if infected patients with abnormal D-dimer are particularly likely to have the worst clinical prognostic risk and to evaluate the strength of the evidence. RESULTS Our results found a significant relationship between D-dimer and COVID-19, with a pooled OR of 1.90 (95% CI: 1.32-2.48; P<0.001). The pooled data was calculated with the REM as a high heterogeneity within the studies. The sensitivity analysis results showed that the WMD ranged from 1.69 (95% CI: 1.15 to 2.23) to 2.06 (95% CI: 1.51 to 2.62) and there was no publication bias. CONCLUSIONS Our meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. Meanwhile, the severe COVID-19 patients tend to have a higher concentration of D-dimer when compared with non-severe patients.
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International_journal_of_clinical_practice
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D-dimer levels is associated with severe COVID-19 infections: A meta-analysis.
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