PropertyValue
?:abstract
  • The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved multiple strategies to evade innate immune response to facilitate viral replication, transmission, and pathogenesis. This review summarizes the recent progresses on SARS-CoV-2 proteins that antagonize host IFN-I production and/or signaling. These progresses have provided knowledge for new vaccine and antiviral development to prevent and control COVID-19.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1089/jir.2020.0214
?:journal
  • J_Interferon_Cytokine_Res
?:license
  • cc-by-nc
?:pdf_json_files
  • document_parses/pdf_json/9ecb783cf8aa133d126b6fd0067981754db7c820.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7757701.xml.json
?:pmcid
?:pmid
?:pmid
  • 33337934.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2
?:type
?:year
  • 2020-12-01

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