PropertyValue
?:abstract
  • INTRODUCTION: Hydroxychloroquine was recently promoted in patients infected with COVID-19 infection. A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice. OBJECTIVE: The present study was undertaken to investigate the reality of this putative drug–drug interaction between hydroxychloroquine and metformin using pharmacovigilance data. METHODS: Using VigiBase(®), the WHO pharmacovigilance database, we performed a disproportionality analysis (case/non-case study). Cases were reports of fatal outcomes with the drugs of interest and non-cases were all other reports for these drugs registered between 1 January 2000 and 31 December 2019. Data with hydroxychloroquine (or metformin) alone were compared with the association hydroxychloroquine + metformin. Results are reported as ROR (reporting odds ratio) with their 95% confidence interval. RESULTS: Of the 10,771 Individual Case Safety Reports (ICSR) involving hydroxychloroquine, 52 were recorded as ‘fatal outcomes’. In comparison with hydroxychloroquine alone, hydroxychloroquine + metformin was associated with an ROR value of 57.7 (23.9–139.3). In comparison with metformin alone, hydroxychloroquine + metformin was associated with an ROR value of 6.0 (2.6–13.8). CONCLUSION: Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed suicides) than one of the two drugs when given alone.
?:creator
?:doi
?:doi
  • 10.1007/s40264-020-00955-y
?:journal
  • Drug_Saf
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/181763c636db0a620fc857e9ce98bae80dbe8cc9.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7269161.xml.json
?:pmcid
?:pmid
?:pmid
  • 32495148.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study
?:type
?:year
  • 2020-06-03

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