PropertyValue
?:abstract
  • Interleukin-6 (IL-6) binds to IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study we performed Systematic Evolution of Ligands by Exponential enrichment (SELEX) and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 nM, but also inhibited the interaction of IL-6R with IL-6.
?:creator
?:doi
?:doi
  • 10.1093/bbb/zbaa124
?:externalLink
?:journal
  • Biosci_Biotechnol_Biochem
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/1b27d7dd4381e5a46f5463406cd3394f200a2878.json
?:pmcid
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • In vitro selection of an RNA aptamer yields an interleukin-6/interleukin-6 receptor interaction inhibitor
?:type
?:year
  • 2021-01-02

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