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SESSION TITLE: Chest Infections Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: The novel Sars-CoV-2 virus causes a viral pneumonia (COVID-19) and corticosteroids have been shown to prolong viral shedding and may increase mortality in viral pneumonias(1) Patients with asthma typically require inhaled corticosteroids It is unknown if asthmatics will therefore have worse outcomes as a result METHODS: This is a retrospective cohort study of asthmatics compared to the general population diagnosed with COVID-19 pneumonia from a multicenter health system in Kansas City The primary outcome is admission to a hospital Secondary outcomes include mechanical ventilatory support and in-hospital all-cause mortality RESULTS: In this cohort, asthmatics had an average BMI of 32 9 +- 3 2, as compared to 31 2+-0 8 in the general population Mean age is 49 0 +- 6 0 vs 54+-1 79 As of 5/1/2020 there have been 345 patients positive for COVID 19 24 have asthma 7/24 with asthma (29 2%) vs 79/321 non-asthmatics (24 6%, OR 1 26, p=0 6) have required admission to a hospital 2/24 (8 3%) asthmatics have required mechanical ventilation vs 17/321 (5 2%, OR 1 49, p=0 6) non-asthmatics 0 asthmatics have died and 7/321 (2 8%, OR 0 8, p=0 9) non-asthmatics have died CONCLUSIONS: In conclusion, based on this limited retrospective data, asthma does not appear to be a significant risk factor for hospital admission, mechanical ventilation, or death CLINICAL IMPLICATIONS: Larger, prospective studies are needed to ensure asthmatics are not at increased risk of worse outcomes due to COVID-19 DISCLOSURES: No relevant relationships by Ibrahim Alakhras, source=Web Response No relevant relationships by Hashaam Arshad, source=Web Response No relevant relationships by Taylor Brinton, source=Web Response No relevant relationships by Ain Ejaz, source=Web Response no disclosure on file for Gregory Howell
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