PropertyValue
?:abstract
  • SARS-CoV-2, the virus causing COVID-19, has infected millions and has caused hundreds of thousands of fatalities. Risk factors for critical illness from SARS-CoV-2 infection include male gender, obesity, diabetes, and age >65. The mechanisms underlying the susceptibility to critical illness are poorly understood. Of interest, these comorbidities have previously been associated with increased signaling of Th17 cells. Th17 cells secrete IL-17A and are important for clearing extracellular pathogens, but inappropriate signaling has been linked to acute respiratory distress syndrome. Currently there are few treatment options for SARS-CoV-2 infections. This review describes evidence linking risk factors for critical illness in COVID-19 with increased Th17 cell activation and IL-17 signaling that may lead to increased likelihood for lung injury and respiratory failure. These findings provide a basis for testing the potential use of therapies directed at modulation of Th17 cells and IL-17A signaling in the treatment of COVID-19.
?:creator
?:doi
?:doi
  • 10.4049/jimmunol.2000554
?:journal
  • Journal_of_immunology
?:license
  • unk
?:pmid
?:pmid
  • 32651218
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • A Case for Targeting Th17 Cells and IL-17A in SARS-CoV-2 Infections.
?:type
?:year
  • 2020-07-10

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