PropertyValue
?:abstract
  • The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posed an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M(pro)) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of the two key targets above. Different classes of inhibitors individually targeting M(pro) and RdRP have been discussed, which could promote drug development to treat SARS-CoV-2 infection.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1016/j.bbrc.2020.10.091
?:journal
  • Biochem_Biophys_Res_Commun
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/4495d10cb5f2efe87bc71684f40dcd9454fef554.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7680044.xml.json
?:pmcid
?:pmid
?:pmid
  • 33288200.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
?:type
?:year
  • 2020-11-21

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