PropertyValue
?:abstract
  • Several studies have reported clinical manifestations of the new coronavirus disease. However, few studies have systematically evaluated the neuropsychiatric complications of COVID-19. We reviewed the medical records of 201 patients with confirmed COVID-19 (52 outpatients and 149 inpatients) that were treated in a large referral center in Tehran, Iran from March 2019 to May 2020. We used clustering approach to categorize clinical symptoms. One hundred and fifty-one patients showed at least one neuropsychiatric symptom. Limb force reductions, headache followed by anosmia, hypogeusia were among the most common neuropsychiatric symptoms in COVID-19 patients. Hierarchical clustering analysis showed that neuropsychiatric symptoms group together in three distinct groups: anosmia and hypogeusia; dizziness, headache, and limb force reduction; photophobia, mental state change, hallucination, vision and speech problem, seizure, stroke, and balance disturbance. Three non-neuropsychiatric cluster of symptoms included diarrhea and nausea; cough and dyspnea; and fever and weakness. Neuropsychiatric presentations are very prevalent and heterogeneous in patients with coronavirus 2 infection and these heterogeneous presentations may be originating from different underlying mechanisms. Anosmia and hypogeusia seem to be distinct from more general constitutional-like and more specific neuropsychiatric symptoms. Skeletal muscular manifestations might be a constitutional or a neuropsychiatric symptom.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1038/s41598-020-78050-6
?:journal
  • Sci_Rep
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/401988aa865c945ba9a920577f8780c67cfeae20.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7708626.xml.json
?:pmcid
?:pmid
?:pmid
  • 33262404.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Neuropsychiatric manifestations of COVID-19 can be clustered in three distinct symptom categories
?:type
?:year
  • 2020-12-01

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