PropertyValue
?:abstract
  • Plasma specimens from COVID-19 patients were double-tested for anti-SARS-CoV-2 antibodies by two different batches of MAGLUMI™ 2019-nCov IgM/IgG assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and (ii) measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3 % of specimens measured for IgM, (iv) the informative time-course pattern of antibody production only when data from different immunoassay batches are not combined. This article is protected by copyright. All rights reserved.
is ?:annotates of
?:creator
?:journal
  • J._med._virol
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • Interpretive discrepancies caused by target values inter-batch variations in chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG by MAGLUMI™
?:type
?:who_covidence_id
  • #33079389
?:year
  • 2020

Metadata

Anon_0  
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/net/provenance/ns#DataItem>
<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
<http://xmlns.com/foaf/0.1/primaryTopic> <https://research.tib.eu/covid-19/entity/z5iwqa5p>
<http://xmlns.com/foaf/0.1/topic> Anon_0
<http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes> <https://research.tib.eu/covid-19/data/entity/z5iwqa5p>
<http://purl.org/net/provenance/ns#createdBy>
Anon_1   (more)
expand all