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SESSION TITLE: Medical Student/Resident Chest Infections Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: We present a case of undiagnosed lung abscess with Coronavirus 2019 CASE PRESENTATION: A 71-year-old female with history of right lower lobe (RLL) lesion (noted six years ago on chest x-ray [CXR]) and 45-pack year smoker presented to the Emergency Room for shortness of breath (SOB) She reported two months of worsening SOB, productive cough, and unintentional weight loss Physical exam revealed RLL wheezes Her oxygen saturation was 89% on room air Admission labs showed leukocytosis and elevated procalcitonin (Table 1) Initial imaging demonstrated a large RLL multiloculated lung abscess (LA) (Figure 1) We initiated oxygen and intravenous (IV) broad spectrum antibiotics Coronavirus 2019 (COVID-19) came back positive and hydroxychloroquine was started Thoracentesis of the LA revealed Streptococcus (Strep) anginosus that was susceptible to penicillins The patient was then switched to Amoxicillin for 4 weeks Repeat Computed Tomography (CT) of chest after 4 weeks revealed RLL consolidation evolution with decreased parenchymal fluid loculations (Figure 2) The pulmonologist restarted Amoxicillin for 4 weeks, ordered repeat COVID-19 testing, and referred to oncology DISCUSSION: A LA is a cavity of the pulmonary parenchyma filled with fluid caused by infection or necrotic debris They remain a significant cause of morbidity and mortality, despite antibiotic treatment, with an incidence rate of 15-20% [1] Our patient likely has a chronic, secondary LA as the onset was greater than 4 weeks and has an underlying lesion They commonly develop, at an incidence rate of 26-80%, from aspiration pneumonia via oral anaerobes Polymicrobial LA are also seen with aerobic bacteria, frequently Strep species The Strep milleri group contains 3 different species, one of which is Strep anginosus These bacteria are part of the oral flora, but can also cause LA [2] Our cultures only grew Strep anginosus, which is atypical We did not observe any acute risk factors of aspiration or immunosuppression, but the patient does have remote history of dental abscess, IV drug use, and alcoholism The patient presented with acute COVID-19 which causes cough and mild fever, but can progress to severe dyspnea and hypoxemia On CT, initial findings are subpleural ground glass opacities and after 2 weeks multiple, large consolidations are seen in the subpleural lower lobes The lesion is gradually absorbed with residual findings of ground glass opacities and parenchymal bands [3] Our patient’s CT was consistent with COVID-19 pneumonia However, the RLL consolidation was noted on CXR from six years ago and after 4 weeks of amoxicillin from this admission, which suggests a chronic process We believe the LA has been present and asymptomatic for years, but the patient did not present until her COVID-19 infection CONCLUSIONS: We illustrate how LA can remain undiagnosed until exacerbated by an acute process Reference #1: Bartlett JG Anaerobic Bacterial Infections of the Lung Chest 1987;91(6):901-909 Reference #2: Mukae H, Noguchi S, Naito K, et al The Importance of Obligate Anaerobes and the Streptococcus anginosus Group in Pulmonary Abscess: A Clone Library Analysis Using Bronchoalveolar Lavage Fluid Respiration 2016;92:80-89 Reference #3: Wu J, Wu X, Zeng W, et al Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features Investigative Radiology 2020;55(5):257-261 DISCLOSURES: No relevant relationships by James Choi, source=Web Response No relevant relationships by Rakesh Gami, source=Web Response No relevant relationships by Tyler Kemnic, source=Web Response No relevant relationships by Jason Liu Liu, source=Web Response No relevant relationships by Rohan Prasad, source=Web Response No relevant relationships by Fazal Raziq, source=Web Response
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