zdrchbd1

Property	Value
?:abstract	OBJECTIVES: The early infection dynamics of patients with SARS-CoV-2 are not well understood. We aimed to investigate and characterize associations between clinical, laboratory, and imaging features of asymptomatic and pre-symptomatic patients with SARS-CoV-2. METHODS: Seventy-four patients with RT-PCR-proven SARS-CoV-2 infection were asymptomatic at presentation. All were retrospectively identified from 825 patients with chest CT scans and positive RT-PCR following exposure or travel risks in outbreak settings in Japan and China. CTs were obtained for every patient within a day of admission and were reviewed for infiltrate subtypes and percent with assistance from a deep learning tool. Correlations of clinical, laboratory, and imaging features were analyzed and comparisons were performed using univariate and multivariate logistic regression. RESULTS: Forty-eight of 74 (65%) initially asymptomatic patients had CT infiltrates that pre-dated symptom onset by 3.8 days. The most common CT infiltrates were ground glass opacities (45/48; 94%) and consolidation (22/48; 46%). Patient body temperature (p < 0.01), CRP (p < 0.01), and KL-6 (p = 0.02) were associated with the presence of CT infiltrates. Infiltrate volume (p = 0.01), percent lung involvement (p = 0.01), and consolidation (p = 0.043) were associated with subsequent development of symptoms. CONCLUSIONS: COVID-19 CT infiltrates pre-dated symptoms in two-thirds of patients. Body temperature elevation and laboratory evaluations may identify asymptomatic patients with SARS-CoV-2 CT infiltrates at presentation, and the characteristics of CT infiltrates could help identify asymptomatic SARS-CoV-2 patients who subsequently develop symptoms. The role of chest CT in COVID-19 may be illuminated by a better understanding of CT infiltrates in patients with early disease or SARS-CoV-2 exposure. KEY POINTS: â¢ Forty-eight of 74 (65%) pre-selected asymptomatic patients with SARS-CoV-2 had abnormal chest CT findings. â¢ CT infiltrates pre-dated symptom onset by 3.8 days (range 1-5). â¢ KL-6, CRP, and elevated body temperature identified patients with CT infiltrates. Higher infiltrate volume, percent lung involvement, and pulmonary consolidation identified patients who developed symptoms.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/zdrchbd1_hasAnnotation_C0015967> <https://research.tib.eu/covid-19/entity/zdrchbd1_hasAnnotation_C0332448> <https://research.tib.eu/covid-19/entity/zdrchbd1_hasAnnotation_C1457887> <https://research.tib.eu/covid-19/entity/zdrchbd1_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Varble%2C_Nicole%3B_Blain%2C_Maxime%3B_Kassin%2C_Michael%3B_Xu%2C_Sheng%3B_Turkbey%2C_Evrim_B%3B_Amalou%2C_Amel%3B_Long%2C_Dilara%3B_Harmon%2C_Stephanie%3B_Sanford%2C_Thomas%3B_Yang%2C_Dong%3B_Xu%2C_Ziyue%3B_Xu%2C_Daguang%3B_Flores%2C_Mona%3B_An%2C_Peng%3B_Carrafiello%2C_Gianpaolo%3B_Obinata%2C_Hirofumi%3B_Mori%2C_Hitoshi%3B_Tamura%2C_Kaku%3B_Malayeri%2C_Ashkan_A%3B_Holland%2C_Steven_M%3B_Palmore%2C_Tara%3B_Sun%2C_Kaiyuan%3B_Turkbey%2C_Baris%3B_Wood%2C_Bradford_J>
?:journal	Eur._radiol
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/zdrchbd1_HAS_C1457887_ASSOCIATED_WITH_C0748159>
?:source	WHO
?:title	CT and clinical assessment in asymptomatic and pre-symptomatic patients with early SARS-CoV-2 in outbreak settings
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#910288
?:year	2020

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Value

?:abstract

OBJECTIVES: The early infection dynamics of patients with SARS-CoV-2 are not well understood. We aimed to investigate and characterize associations between clinical, laboratory, and imaging features of asymptomatic and pre-symptomatic patients with SARS-CoV-2. METHODS: Seventy-four patients with RT-PCR-proven SARS-CoV-2 infection were asymptomatic at presentation. All were retrospectively identified from 825 patients with chest CT scans and positive RT-PCR following exposure or travel risks in outbreak settings in Japan and China. CTs were obtained for every patient within a day of admission and were reviewed for infiltrate subtypes and percent with assistance from a deep learning tool. Correlations of clinical, laboratory, and imaging features were analyzed and comparisons were performed using univariate and multivariate logistic regression. RESULTS: Forty-eight of 74 (65%) initially asymptomatic patients had CT infiltrates that pre-dated symptom onset by 3.8 days. The most common CT infiltrates were ground glass opacities (45/48; 94%) and consolidation (22/48; 46%). Patient body temperature (p < 0.01), CRP (p < 0.01), and KL-6 (p = 0.02) were associated with the presence of CT infiltrates. Infiltrate volume (p = 0.01), percent lung involvement (p = 0.01), and consolidation (p = 0.043) were associated with subsequent development of symptoms. CONCLUSIONS: COVID-19 CT infiltrates pre-dated symptoms in two-thirds of patients. Body temperature elevation and laboratory evaluations may identify asymptomatic patients with SARS-CoV-2 CT infiltrates at presentation, and the characteristics of CT infiltrates could help identify asymptomatic SARS-CoV-2 patients who subsequently develop symptoms. The role of chest CT in COVID-19 may be illuminated by a better understanding of CT infiltrates in patients with early disease or SARS-CoV-2 exposure. KEY POINTS: â¢ Forty-eight of 74 (65%) pre-selected asymptomatic patients with SARS-CoV-2 had abnormal chest CT findings. â¢ CT infiltrates pre-dated symptom onset by 3.8 days (range 1-5). â¢ KL-6, CRP, and elevated body temperature identified patients with CT infiltrates. Higher infiltrate volume, percent lung involvement, and pulmonary consolidation identified patients who developed symptoms.

is ?:annotates of