PropertyValue
?:abstract
  • T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4(+) T-cells and cytotoxic CD8(+) T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed. Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19. In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients. Particularly, we highlight the impairment of FOXP3 induction in CD4(+) T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19.
is ?:annotates of
?:creator
?:doi
  • 10.1016/j.bbrc.2020.10.079
?:doi
?:journal
  • Biochem_Biophys_Res_Commun
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/a47b656aa5a1563b9315ef836a442786edf60dfa.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7648511.xml.json
?:pmcid
?:pmid
?:pmid
  • 33220925.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • T-cell dysregulation in COVID-19
?:type
?:year
  • 2020-11-07

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