PropertyValue
?:abstract
  • The emergence of SARS-coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on COVID-19, as well as draw inferences for future investigations.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1016/j.it.2020.10.004
?:journal
  • Trends_Immunol
?:license
  • els-covid
?:pdf_json_files
  • document_parses/pdf_json/097a0f0227e28a62b21048f028779fb56a06cb16.json
?:pmcid
?:pmid
?:pmid
  • 33132005.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Elsevier; Medline; PMC
?:title
  • Mechanisms of SARS-CoV-2 transmission and pathogenesis
?:type
?:year
  • 2020-10-14

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