PropertyValue
?:abstract
  • The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication was observed in animals when the drug was administered either beginning 12 hours before or 12 hours following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans following high-risk exposure as well as for treatment of COVID-19 patients.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.21203/rs.3.rs-86289/v1
?:journal
  • Res_Sq
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/6818af7f6a073eec7b72595c98b987e83a7af8fe.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7553153.xml.json
?:pmcid
?:pmid
?:pmid
  • 33052329.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
?:type
?:year
  • 2020-10-08

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