PropertyValue
?:abstract
  • The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has elicited a global health crisis of catastrophic proportions. With only a few vaccines approved for early or limited use, there is a critical need for effective antiviral strategies. In this study, we report a unique antiviral platform, through computational design of ACE2-derived peptides which both target the viral spike protein receptor binding domain (RBD) and recruit E3 ubiquitin ligases for subsequent intracellular degradation of SARS-CoV-2 in the proteasome. Our engineered peptide fusions demonstrate robust RBD degradation capabilities in human cells and are capable of inhibiting infection-competent viral production, thus prompting their further experimental characterization and therapeutic development.
is ?:annotates of
?:creator
?:doi
  • 10.1038/s42003-020-01470-7
?:doi
?:journal
  • Commun_Biol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/b8e69fa00cb9e90e48340337cf69db7dc76db884.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7683566.xml.json
?:pmcid
?:pmid
?:pmid
  • 33230174.0
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:sha_id
?:source
  • Medline; PMC
?:title
  • Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions
?:type
?:year
  • 2020-11-23

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