PropertyValue
?:abstract
  • Abstract B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27?, CD21?) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either ?driver or passenger? of hyperinflammation during COVID-19 needs to be clarified
  • B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27(-), CD21(-)) atypical memory B cells and (CD19(+), CD27(+), CD38(+)) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73(+) B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either \'driver or passenger\' of hyperinflammation during COVID-19 needs to be clarified
  • B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibodies, but also as APCs and mediators of inflammation In this study, we used 16-color flow cytometry analysis to investigate the frequency, differentiation, and activation status of peripheral B cells of patients with SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared with the healthy individuals As a main result, we observed an increase of the frequency of (CD27–, CD21–) atypical memory B cells and (CD19+, CD27+, CD38+) plasmablasts in malaria and COVID-19 patients Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereas CD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared with the bulk B cell population In particular, there was a more pronounced loss of CD73+ B cells in malaria The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, and LDH of COVID-19 patients In the longitudinal course of COVID-19, a rapid normalization of the frequency of atypical memory B cells was observed The role and function of plasmablasts and atypical memory B cells in COVID-19 and other acute infections remain to be further investigated The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needs to be clarified
is ?:annotates of
?:creator
?:journal
  • Journal_of_Leukocyte_Biology
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • B cell analysis in SARS-CoV-2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID-19
?:type
?:who_covidence_id
  • #1023293
  • #956712
  • #978134
?:year
  • 2020
  • 2021

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